Injectable silanized hyaluronic acid hydrogel/biphasic calcium phosphate granule composites with improved handling and biodegradability promote bone regeneration in rabbits
نویسندگان
چکیده
In situ forming Si-HA/BCP are potent injectable bone substitutes to regenerate defects.
منابع مشابه
Fabrication of calcium phosphate-calcium sulfate injectable bone substitute using chitosan and citric acid.
In this study, an injectable bone substitute (IBS) consisting of citric acid, chitosan solution as the liquid phase and tetra calcium phosphate (TTCP), dicalcium phosphate anhydrous (DCPA) and calcium sulfate hemihydrate (CSH) powders as the solid phase was prepared. Four groups containing different percentages (0-30%) of calcium sulfate hemihydrate (CSH, CaSO(4) . 0.5H(2)O) were investigated. ...
متن کاملPolymer-calcium phosphate composites for use as an injectable bone substitute
Calcium phosphate (CP) materials have been used extensively for bone replacement and augmentation due to their similarity to the mineral component of bone. In addition to being non-toxic, they are biocompatible, not recognized as foreign in the body, and most importantly, exhibit bioactive behavior, being integrated into the tissue by the same processes active in remodeling healthy bone. This l...
متن کاملPolymer-calcium phosphate composites for use as an injectable bone substitute
Medical procedures to address bone related injury are prevalent in the United States, with around 900,000 hospitalizations due to fractures and over 800,000 grafting procedures annually. Calcium phosphates (CPs) are particularly promising as bone substitute materials, due to their similarity to hydroxyapatite, the mineral component of bone. In addition to being non-toxic, they are biocompatible...
متن کاملA Novel Injectable Calcium Phosphate Cement-Bioactive Glass Composite for Bone Regeneration
BACKGROUND Calcium phosphate cement (CPC) can be molded or injected to form a scaffold in situ, which intimately conforms to complex bone defects. Bioactive glass (BG) is known for its unique ability to bond to living bone and promote bone growth. However, it was not until recently that literature was available regarding CPC-BG applied as an injectable graft. In this paper, we reported a novel ...
متن کاملBone regeneration: molecular and cellular interactions with calcium phosphate ceramics
Calcium phosphate bioceramics are widely used in orthopedic and dental applications and porous scaffolds made of them are serious candidates in the field of bone tissue engineering. They have superior properties for the stimulation of bone formation and bone bonding, both related to the specific interactions of their surface with the extracellular fluids and cells, ie, ionic exchanges, superfic...
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ژورنال
عنوان ژورنال: Biomaterials Science
سال: 2021
ISSN: ['2047-4849', '2047-4830']
DOI: https://doi.org/10.1039/d1bm00403d